Inflammation has gotten a lot of publicity lately and for good reason. It is now thought that chronic inflammation within your body increases the risk of you developing multiple degenerative problems, such as cancers, heart disease, and Alzheimer’s disease. In addition, certain conditions, such as obesity and diabetes, increase the inflammation in your body which is thought to age you prematurely.

Thus, if there is something we all can do to decrease inflammation within our bodies, we can potentially decrease the accelerating aging process, or what we call anti-aging actions. Recently, a biologic switch that turns on and generates inflammation in your body has been recognized. This “switch”, is HMGB1 (High Mobility Group Box-1) turns on the release of certain chemicals called cytokines. These can result in increased inflammation inside your body.

The more inflammation you have in your body, the more rapidly your body ages prematurely and chronic disease can progress more rapidly. (1, 2) If you can “turn off” this switch, potentially you can halt this process. Researchers have found two naturally occurring products that can directly control HMGB1 and potentially reduce your body’s exposure to chronic inflammation, ultimately protecting you against inflammation-induced disorders. (3, 4)

These two products are Mung bean and green tea extract. They combat inflammation by interfering with the cascade of events that leads to HMGBI turning on and subsequently releasing cytokines into your system. This is particularly important to reduce these from damaged or stressed cells. (3-10)

Multiple studies have proven the effectiveness of these two natural products to reduce cytokine levels. (3, 4, 11-14). Thus, using these preparations could help you reduce inflammation within your body and help decrease your risk of developing many degenerative problems.

Mung beans and green tea have been used for thousands of years in traditional Chinese medicine. Now we know why they work so well for they turn off the HMGB1 switch to decrease inflammation. You can get these compounds in a supplement called “Cytokine Suppress”, available through our office.

Another method to decrease inflammation is to reduce the inflammatory toxins from your gut from entering into your body. As we age, the ability of our intestines to fight off the toxins within our gut decreases. This has been called “leaky gut”. Two natural substances that may help you reduce this from occurring are IgG and glutamine.

IgG is an immunoglobulin which can neutralize endotoxins found in your intestines and thus reduce the inflammation within your gut. Oral supplementation has been shown to preserve gut wall integrity and provide intestinal immunity. (15)

Glutamine is a natural amino acid that is important in the binding of the cells lining your intestines. By strengthening this binding, less inflammatory inducing agents enter between these cells, thus decreasing the inflammation entering your body. It thus is very important for maintaining gastrointestinal integrity and also it stimulates immune cell functioning.

Glutamine helps heal broken junctions of these GI cells. It is an important transporter of nitrogen (and carbon) in the body and therefore, is vital in wound healing. Although glutamine can be synthesized by the intestinal mucosa, during periods of physiological stress, your body’s needs for this protein increase and your body can not likely meet the need that your gut epithelia require. Thus it is recommended that you supplement your body’s needs. This can be done easily with a preparation called GI Protect, available at our office.

For further information on anti-aging and ways to decrease inflammation, call for a consultation to our office at 817-399-8783.

References:

  1. Nogueira-Machado JA, de Oliveira Volpe CM. HMGB-1 as a target for inflammation controlling. Recent Pat Endocr Metab Immune Drug Discov. 2012 Sep;6(3):201-9.
  2. Strzelecka M, Bzowska M, Kozieł J, et al. Anti-inflammatory effects of extracts from some traditional Mediterranean diet plants. J Physiol Pharmacol. 2005 Mar;56 Suppl 1:139-56.
  3. Li W, Ashok M, Li J, Yang H, Sama AE, Wang H. A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1. PLoS One. 2007;2(11):e1153.
  4. Zhu S, Li W, Li J, Jundoria A, Sama AE, Wang H. It is not just folklore: The aqueous extract of mung bean coat is protective against sepsis. Evid Based Complement Alternat Med. 2012;2012:498467.
  5. Chen X, Li W, Wang H. More tea for septic patients?–Green tea may reduce endotoxin-induced release of high mobility group box 1 and other pro-inflammatory cytokines. Med Hypotheses. 2006;66(3):660-3.
  6. Kuang X, Huang Y, Gu HF, et al. Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats. Eur J Pharmacol. 2012 Feb 15;676(1-3):51-6.
  7. Li W, Zhu S, Li J, et al. EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages. Biochem Pharmacol. 2011 May 1;81(9):1152-63.
  8. Saiwichai T, Sangalangkarn V, Kawahara K, et al. Green tea extract supplement inhibition of HMGB1 release in rats exposed to cigarette smoke. Southeast Asian J Trop Med Public Health. 2010 Jan;41(1):250-8.
  9. Burnett BP, Levy RM. 5-Lipoxygenase metabolic contributions to NSAID-induced organ toxicity. Adv Ther. 2012 Feb;29(2):79-98.
  10. Cao D, Li H, Yi J, et al. Antioxidant properties of the mung bean flavonoids on alleviating heat stress. PLoS One. 2011;6(6):e21071.
  11. Cai B, Deitch EA, Ulloa L. Novel insights for systemic inflammation in sepsis and hemorrhage. Mediators Inflamm. 2010;2010:642462.
  12. Khalil AA, Hall JC, Aziz FA, Price P. Tumour necrosis factor: implications for surgical patients. ANZ J Surg. 2006 Nov;76(11):1010-6.
  13. Qiu P, Cui X, Barochia A, Li Y, Natanson C, Eichacker PQ. The evolving experience with therapeutic TNF inhibition in sepsis: considering the potential influence of risk of death. Expert Opin Investig Drugs. 2011 Nov;20(11):1555-64.
  14. Sama AE, D’Amore J, Ward MF, Chen G, Wang H. Bench to bedside: HMGB1-a novel proinflammatory cytokine and potential therapeutic target for septic patients in the emergency department. Acad Emerg Med. 2004 Aug;11(8):867-73.
  15. Dickinson EC, Gorga JC, Garrett M et al. Immunoglobulin A supplementation abrogates bacterial translocation and preserves the architecture of the intestinal epithelium. Surgery 1998;124:284-90