Arterosil is a dietary supplement that contains rhamnan sulfate, a compound found in green seaweed (monostroma nitidum), which grows in Asia. It helps improve the health of the inside lining of your arteries, called the endothelial glycocalyx. Damage occurs to the endothelial glycocalyx we age from multiple causes, and this damage develops into cardiovascular disease.

The glycocalyx of the endothelium is like a fuzzy coating of all your vessels that contains heparin, a blood thinner, and chondroitin sulfate. It forms a slick coating inside your arteries that allows the blood to flow freely inside of the arteries without hurting the glycocalyx. You can read more about the glycocalyx in my blog article on it.

Functions of Rhamnan

Rhamnan is a polysaccharide, i.e. a substance made from a bunch of glucose molecules bound together; sort of like the glycogen that your body makes. It has a negative charge to it, sort of like a magnet that has a positive and a negative. If you put the ends of two magnets opposite each other they repel each other.

Rhamnan sulfate (the natural salt form) has a similar chemical structure to heparan sulfate, which is known to be an anticoagulant, and is found abundantly in the glycocalyx. Thus, Rhamnan may bioactively repair or regenerate the glycocalyx. It has been shown to have anticoagulant and antithrombotic activities,[1] similar to heparin.

The glycocalyx that covers the endothelium not only prevents clotting of the blood (by the heparin) and is slick (by the chondroitin), but it also has a negative charge to it. Think of it like millions of microscopic magnets that repel other negatively charged substances and prevent them from injuring the endothelial cells, in addition to white blood cells, red blood cells and platelets.[2]

Rhamnan helps build and repair this glycocalyx so it functions better. Since Rhamnan also has a negative charge to it, it is thought to assist in the power of the endothelium to repel negative charges and allow the blood and substances within the blood to flow more freely.

Clinical studies of Ramnan, trade name Arterosil, have shown that it can repair and rejuvenate compromised glycocalyx. Arterosil supplementation ameliorates the damage of endothelial glycocalyx and the loss of endothelial function via many pathways, including an immunomodulatory one to decrease inflammation, and cytotoxic effects on undesirable cells, such as cancer cells.[3] A summary of the many ways arterosil improves your endothelium are schematically represented in the attached diagram.


Arterosil is a dietary supplement that contains rhamnan sulfate derived from green seaweed monostroma nitidum. It is phytonutrient supplement that can be used by the human body as building blocks for its vascular and/ or microvascular glycocalyx.

Arterosil has been thoroughly studied and researched. It is the first and only product that has been proven to be safe and effective to help maintain a healthy endothelial glycocalyx and its mediated endothelial function.

Arterosil is available from many physicians who practice preventive medicine. In addition, embracing a healthy lifestyle may also help improve the glycocalyx of the endothelium of your vessels. For further information, contact TrueMD or your local physician.

Disclaimer: Information in this blog article has not been evaluated by the FDA. Arterosil is a branded nutraceutical. It and the information contained herein is not intended to diagnose, treat or cure any disease. As with all supplements, you should discuss use of this supplement with your physician.


[1]  Mao WJ, Fang F, et al. Heparinoidactive Two Sulfated Polysaccharides Isolated from Marine Green Algae monstroma nitidum. Carbohydrate Polymers (2008) 74:834-839.

[2] Reitsma S, Slaaf DW, Vink H, van Zandvoort MA, Oude Egbrink MG. The endothelial glycocalyx: composition, functions, and visualization. Pflugers Archiv: European Journal of Physiology 2007; 454: 345–59.

[3] Kamjanapratum S, You SG. Molecular characteristics of sulfated polysaccharides from Monostroma nitidum and their in vitro anticancer and immunomodulatory activities. Intern J of Biolog Macromolecules. 48(2), March 2011:3110318.