Peptides are chains of amino acids that signal microscopic actions within your cells to improve their efficiency and their functions. Certain peptides can enhance your sex life by acting in your brain to boost your libido, sexual desire, and satisfaction from sex. This occurs in both a man and a woman, plus they help men who have problems with erectile dysfunction (E.D.) Boost your mojo!

Low Sex Drive

Many women and men suffer from low sex drive. Much of this is due to low testosterone levels that occurs as you age and other factors that affect libido. Thus, the first thing you want to do if you have this problem is to make sure your hormones of estrogen and/or testosterone are boosted to optimal levels to help improve sex drive and performance. Getting a healthier body also helps, such as losing weight and eating right. However, sometimes this just isn’t enough and you need more.

A recent poll found that 53% of women want more sex than their sexual partner provides. A condition called hypoactive sexual desire disorder (HSDD) is very common in women, occurring in around 43% of women. Unfortunately, there are very few medications for women to correct this. Sex drive does encompass a variety of actions and concepts. For men, usually they just need their willing partner. However, erectile dysfunction occurs in 30 million men.

For women, it can become a lot more complicated.  Women’s needs may include more romance and caring. They may nee more empathy, sincerity, commitment, and honesty. They may need to be attracted to her sexual partner mentally or physically and have created a bond with the partner of trust and reliability. Plus, they need a willing partner too. Everyone is different.

Medical conditions can also alter libido. Diabetes many times has neurological issues that make it difficult for the man to become erect and also decreases his libido. Women diabetics may also suffer. Heart disease, autoimmune diseases and other debilitating diseases can zap one of their energy, resulting in low sex drive and performance.

If her/his emotional needs are adequately fulfilled, hormone levels are boosted to optimal levels, and medical conditions are adequately resolved, if there still is a need for further sexual enhancements, certain peptides may fill this need.

Barbie Doll Peptide

One peptide that improves libido is bromelanotide, or PT-141. It works centrally on the brain to improve libido and sexual performance. This peptide does other things too. It also stimulates the pigments in our skin, called melanocytes, which results in you getting a bit of a tan when used regularly. In addition, it can decrease your appetite, so you could lose weight.

Thus, this is called the Barbie Doll Peptide: it gives you a tan, helps you lose weight, and stimulates your sex drive all at the same time. However, it not only works in women, it also works similarly in men and not only increases a man’s sex drive, it can also improve penile erections.

PT-141 works by binding to receptors in the brain called melanocortin 3 and 4. It then activates these receptors resulting in increased sexual desire and the arousal response.[1] Studies on women who had received PT-141 showed the women’s sexual drive was significantly increase and they were more satisfied with sex within 24 hours after the treatment, compared to those taking placebo.[2] Men also had improved libido plus erections were better; many times ED resolves when PT-141 is used.

Of note, PT-141 does not work on the vascular system as do Viagra and the other PDE5 inhibitors. It works directly on the areas of the brain that increase sexual desire via the nervous system.[3] Thus, it is very useful in women and studies have shown a marked increase in sexually satisfying experiences with it.[4] Men with erectile dysfunction also benefit with PT-141 providing increased erectile activity.[5] Although it is not FDA approved, application has been made.

Another peptide that works in a similar fashion to PT-141 is Melanotan II. It has been shown to increase sexual libido and performance, increases pigmentation of the skin, and decreases appetite similar to PT-141 for they both work on the same area in the brain that enhances libido, both can increase libido, and both have similar side effects. If one doesn’t work, one can always try the other peptide, since each has a slightly different effect on each individual.

Side Effects from PT-141

Generally, studies have demonstrated very little problems from use of PT-141 and it has been found to be safe and well-tolerated. However, there are a few potential side effects that occasionally occur that you need to be aware of.

PT-141 may raise blood pressure, and this problem is rarely seen using the injections. It is common with the nasal sprays, so this route is not recommended. In fact, injections are the only form of PT-141 that is FDA approved, and we prefer to use the injected form to reduce the risk of this potential side effect. In addition, using the injection method is safe to use with alcohol.

In men, PT-141 is very useful particularly for those men who do not respond well to Viagra or similar drugs that correct erectile dysfunction. Sexual satisfaction is significantly increased in men when this peptide is used. Studies have shown significantly greater sexual satisfaction in the group of men using PT-141 compared to those receiving placebo.

Other side effects may include nausea, muscle aches, flushing or headaches. However, for the most part, PT-141 is very well tolerated. In addition, it’s dosage can be variable: it can be using regularly every day, every other day, or as need. Thus, use of the peptide can be tailored to the person’s individual needs and schedule.

In men, the sex enhancing peptides may rarely result in prolonged erections. If this lasts for several hours (called priapism), this could result in injury to the penis, a visit to the ER, and further injury when they try to fix it. For sure, do not use these with Viagra or other PDE5 inhibitors for the chance of getting this problem is increased when the combo is used.

The downside of using the peptides is that their onset of actions is variable depending on the person. In some people, they may be ready for sex in 30 minutes, while in others it may take 6 to 12 hours before it “kicks in”. In addition, it must be injected for best results and it must be refrigerated until used.  Fortunately, the injection is with using a very tiny needle, so the fear of injection goes away rather quickly in most people, especially when they feel the great effects.

Dosage: Normally 0.15 to 0.2 cc of the peptide is administered SQ (in the belly) 2 to 6 hours prior to the sexual event. Some people prefer to take it once or twice daily for maintenance. Results are variable so each individual person may design his/her own dosage schedule according to how they react to it.


Low libido (sexual desire) is a big problem, especially with a woman but some men suffer from this, and some men suffer from erectile dysfunction. There are two peptides that work well for these problems and have shown very significant increases in libido, sexual satisfaction, and correction of ED. Time of onset is variable as is dosage, but effects are very significant for those who need a boost in their sexual life and want to enhance their mojo.


[1] Gelez, H.; Shadiack, A. M.; JG, P. Brain Activation Following Peripheral Administration of the Melanocortin Agonist PT-141. Program No. 418.16. 2005.

[2] Diamond LE. Et al. n Effect on the Subjective Sexual Response in Premenopausal Women with Sexual Arousal Disorder by Bremelanotide (PT‐141), a Melanocortin Receptor Agonist. The Journ of Sexual Med. 3(4) June 2006.

[3] Shadiack AM, et al. Melanocortins in the Treatment of Male and Female Sexual Dysfunction. Current Topics in Medicinal Chem. 7(11)2007:1137-1144.

[4] Clayton AH. Et al. Bremelanotide for Female Sexual Dysfunctions in Premenopausal Women: A Randomized, Placebo-Controlled Dose-Finding Trial. Women’s Health. June 2016.

[5] Molinoff PB, et al. PT‐141: A Melanocortin Agonist for the Treatment of Sexual Dysfunction. Ann NY Acad of Sciences. 994(1) Jan 2006.