Peptides are made of amino acids that tell the body’s cells to do certain functions. They are signaling compounds. One amazing peptide is called BPC-157 and it tells the cells and tissues to “Heal thyself”. It has been used in multiple settings of injury, damage and inflammation with very good results.

The potential uses of this peptide are extensive. They can signal improved healing in joint arthritis, ligament tears, tendonitis, and other orthopedic injuries. Other uses are regarding certain inflammatory medical conditions, such as Crohn’s disease or ulcerative colitis, lupus, and muscular sclerosis (MS). They also are cardio- and neuro-protective too and may prove valuable in many chronic age-related issues such as heart disease and Alzheimer’s disease.

Short History of BPC-157

This peptide was discovered over a hundred years ago in gastric juices (secretions from the stomach), but its function was not appreciated at that time. As you know, your stomach is in almost a constant exposure to hydrochloric acid that helps digest your food. If you were to put hydrochloric acid on your skin, it would burn a hole in your skin. So why doesn’t it burn a hole in your stomach?

The answer is complex, but part of it has to do with the fact that the cells in the lining of your stomach are continuously in a reparative mode. They always are fixing and reproducing more stomach cells because they are continuously being damaged by the hydrochloric acid. In addition, the tiny microvascular blood flow that feeds the cells is also injured along with the tiny nerves that stimulate the functions of the stomach, but these must get repaired too.

So, what stimulates all these different cells to quickly continually heal themselves? Much research suggests that it is BPC-157.[1], [2] This peptide is secreted by the stomach cells and sends signals to the cells of the stomach to essentially fix themselves: reproduce, repair, stimulate growth, and stimulate repair and formation of microvasculature and nerves. In a nutshell you could say that this peptide stimulates repair of damaged tissues.

Repair of Orthopedic Problems

Since BPC-157 can stimulate repair of tissues, it has been used to treat many orthopedic injuries, such as torn ligaments, muscles and tendons.[3] Injections can be made directly into the tissues and can accelerate healing. If many tissues are affected, subcutaneous injections can be done and the peptide will travel to the injury and stimulate the healing process to occur.

Tendons and ligaments heal better and faster. There is improved formation of tissues with an increase in fibroblasts, in collagen fibers, and other structures. Moreover, the structures are less inflamed, and they function at a significantly higher level. Growth factors that produce tissue components and make blood vessels grow into them are increased when the peptide is used.[4] You still need to go through a healing process, but peptides can potentially make them heal faster and better.

Arthritic process may also be stimulated to heal, resulting in repair of the inflamed joints. In addition, pain is decreased too by BPC-157. Thus, those who suffer from painful arthritis could benefit significantly from use of this peptide.

Healing of Inflamed Stomach and Intestinal Tissues

BPC-157 helps prevent ulcerations of stomach tissue by stimulating the healing response. It is thus not surprising that it can heal ulcers[5] and it scan be very beneficial in those autoimmune diseases that are complicated by ulcers of the intestines due to inflammation in those tissues. These can include ulcerative colitis, Crohn’s disease, and Irritable Bowel Syndrome.

One sees less oxidative stress in the tissues with less damage and improved cell survival with use of BPC 157. It increases tissue healing by increasing fibroblast activity, which forms the structures of the intestinal organs. In addition, it increases formation of new vessels into the gut tissues (angiogenesis) which improves blood supply to the tissues to help in the healing process.[6]

BPC157 has been shown to protect the gut from the adverse effects of alcohol and nonsteroidal anti-inflammatory drugs (NSAIDS), which have been shown to increase risk of gastric ulcers.  It also counteracts the effects of cancers to the body. It has been shown to decrease the cachexia, muscle wasting, and inflammatory reactions that are seen in cancers.[7]

Healing Heart and Neurological Damage

Much research has been focused toward improving the health of the vasculature in your body. These vessels must be very healthy to distribute the blood to all areas of your body, including your brain and your heart. BPC 157 has been shown to improve the health of the endothelium, which is the inside lining of all blood vessels.

Just like it heals the stomach, it can heal and repair damage to the endothelium, which subsequently helps to maintains a healthier state and protects the endothelium from further damage (cardioprotective). It can help improve the healing of endothelial tissue that had been damage by multiple mechanisms, including high blood pressure, clotting, thrombosis, etc. It dilates the vessels to improve circulation and stimulates the growth of new vessels.[8]

There has been much research on stimulation of the healing process by BPC-157 on the brain. It appears that it is neuroprotective and can also stimulate repair of neurological damage. It improves nerve regeneration, decreases inflammation of the neurons, and influences many neurotransmitter systems, including serotonergic, dopaminergic, opioid and GABAergic systems.[9]

Because BPC-157 appears to help stimulate the healing of damaged tissues and help in their regeneration, it may counteract the otherwise progressive courses of injuries to the neurons, including traumatic brain issues.[10] Moreover, because of its healing signaling, it is speculated that it may help in chronic age-related neurological issues such as Alzheimer’s disease or Parkinson’s disease.

Dosage: BPC-157 is usually given by an injection below the skin (SQ) at 0.15 cc to 3.0 cc daily. Normally improvement in healing of orthopedic problems is seen within 2 to 4 weeks of use of this peptide. A dose of 0.15 cc may be all that is necessary for long term protective effects.

Summary

BPC 157 is a peptide that stimulates the healing of tissues and can accelerate healing in multiple organs. It can help repair tendons, muscles and ligaments plus help heal arthritic conditions. It is very beneficial in healing gut issues and can help treat chronic inflammatory issues of the gut such as ulcers, Ulcerative colitis and Crohn’s disease. It is also protective for the brain and the heart. When damaged tissue is present, this peptide can help heal it and make this happen faster for better health and to improve your quality of life.

 

References:

[1] Sikiric P,    et al. Stable Gastric Pentadecapeptide BPC 157-NO-system Relation. Current Pharmaceutical Design, 20(7), 2014:1126-1135(10).

[2] Xue X-C. Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats. World J Gastroenterol. 2004 Apr 1; 10(7): 1032–1036. 2004 Apr 1. doi: 10.3748/wjg.v10.i7.1032

[3] Gwyer, D., Wragg, N.M. & Wilson, S.L. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res 377, 153–159 (2019) doi:10.1007/s00441-019-03016-8

[4] Vukojević J, Siroglavić M, Kašnik K, Kralj T, Stanćić D, Kokot A, Kolarić D, Drmić D, Sever AZ, Barišić I, Šuran J (2018) Rat inferior caval vein (ICV) ligature and particular new insights with the stable gastric pentadecapeptide BPC 157. Vasc Pharmacol 106:54–66. doi.org/10.1016/j.vph.2018.02.010

[6] Duzel A, et al. Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfuction in rates: new insights. World J Gastroenterol. 2017;23(48):846588. doi: 10.3748/wjg.v23.i48.8465

[7] Sikiric P, HahmKB, Blagaic AB, Tvrdeic A, Pavlov KH, Petrovic A, Kokot A, GojkovicS, Krezic I, Drmic D, Rucman R, Seiwerth S. Stable Gastric Pentadecapeptide BPC 157, Robert’s Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selye’s Stress Coping Response: Progress, Achievements, and the Future.  Gut Liver. 2019 Jun 4. doi: 10.5009/gnl18490

[8] Sven Seiwerth*, Luka Brcic, LovorkaBateljaVuletic, Danijela Kolenc, GoranaAralica, MarijaMisic, Anita Zenko, DomagojDrmic, Rudolf Rucman and PredragSikiric, BPC 157 and Blood Vessels , Current Pharmaceutical Design, 2014, 20, 1121-1125

[9] Sikiric P, et al. Brain-gut axis and pentadecapeptide BPC 157: Theoretical and practical implications. Curr Neuropharmacol. 2016;14:857-65.

[10] IBID