The health of your heart has a lot to do with how well it is nourished. Just like all other organs of your body, your heart is nourished by the arteries that bring those nutrients and oxygen to your heart. Having healthy blood vessels is thus key to maintaining a healthy heart. (more…)
Arterosil is a dietary supplement that contains rhamnan sulfate, a compound found in green seaweed (monostroma nitidum), which grows in Asia. It helps improve the health of the inside lining of your arteries, called the endothelial glycocalyx. Damage occurs to the endothelial glycocalyx we age from multiple causes, and this damage develops into cardiovascular disease.
The glycocalyx of the endothelium is like a fuzzy coating of all your vessels that contains heparin, a blood thinner, and chondroitin sulfate. It forms a slick coating inside your arteries that allows the blood to flow freely inside of the arteries without hurting the glycocalyx. You can read more about the glycocalyx in my blog article on it.
Functions of Rhamnan
Rhamnan is a polysaccharide, i.e. a substance made from a bunch of glucose molecules bound together; sort of like the glycogen that your body makes. It has a negative charge to it, sort of like a magnet that has a positive and a negative. If you put the ends of two magnets opposite each other they repel each other.
Rhamnan sulfate (the natural salt form) has a similar chemical structure to heparan sulfate, which is known to be an anticoagulant, and is found abundantly in the glycocalyx. Thus, Rhamnan may bioactively repair or regenerate the glycocalyx. It has been shown to have anticoagulant and antithrombotic activities, similar to heparin.
The glycocalyx that covers the endothelium not only prevents clotting of the blood (by the heparin) and is slick (by the chondroitin), but it also has a negative charge to it. Think of it like millions of microscopic magnets that repel other negatively charged substances and prevent them from injuring the endothelial cells, in addition to white blood cells, red blood cells and platelets.
Rhamnan helps build and repair this glycocalyx so it functions better. Since Rhamnan also has a negative charge to it, it is thought to assist in the power of the endothelium to repel negative charges and allow the blood and substances within the blood to flow more freely.
Clinical studies of Ramnan, trade name Arterosil, have shown that it can repair and rejuvenate compromised glycocalyx. Arterosil supplementation ameliorates the damage of endothelial glycocalyx and the loss of endothelial function via many pathways, including an immunomodulatory one to decrease inflammation, and cytotoxic effects on undesirable cells, such as cancer cells. A summary of the many ways arterosil improves your endothelium are schematically represented in the attached diagram.
Arterosil is a dietary supplement that contains rhamnan sulfate derived from green seaweed monostroma nitidum. It is phytonutrient supplement that can be used by the human body as building blocks for its vascular and/ or microvascular glycocalyx.
Arterosil has been thoroughly studied and researched. It is the first and only product that has been proven to be safe and effective to help maintain a healthy endothelial glycocalyx and its mediated endothelial function.
Arterosil is available from many physicians who practice preventive medicine. In addition, embracing a healthy lifestyle may also help improve the glycocalyx of the endothelium of your vessels. For further information, contact TrueMD or your local physician.
Disclaimer: Information in this blog article has not been evaluated by the FDA. Arterosil is a branded nutraceutical. It and the information contained herein is not intended to diagnose, treat or cure any disease. As with all supplements, you should discuss use of this supplement with your physician.
 Mao WJ, Fang F, et al. Heparinoidactive Two Sulfated Polysaccharides Isolated from Marine Green Algae monstroma nitidum. Carbohydrate Polymers (2008) 74:834-839. https://doi.org/10.1016/j.carbpol.2008.04.041
 Reitsma S, Slaaf DW, Vink H, van Zandvoort MA, Oude Egbrink MG. The endothelial glycocalyx: composition, functions, and visualization. Pflugers Archiv: European Journal of Physiology 2007; 454: 345–59. https://link.springer.com/article/10.1007/s00424-007-0212-8
 Kamjanapratum S, You SG. Molecular characteristics of sulfated polysaccharides from Monostroma nitidum and their in vitro anticancer and immunomodulatory activities. Intern J of Biolog Macromolecules. 48(2), March 2011:3110318. https://doi.org/10.1016/j.ijbiomac.2010.12.002
Testosterone is very beneficial to your health and new studies suggest that you may even live longer if you don’t have “Low-T”. One recent study found that low testosterone levels be actually be harmful and even deadly. Moreover, having more testosterone appears to help you live longer and with better quality of life. These researchers revealed findings that not having enough testosterone can be deadly for your heart.
In the October edition of a highly respected clinical journal on metabolism, these researchers evaluated around 4,000 thousand people and followed them for over five years. Their conclusion was that people who had the least free testosterone were 71% more likely to die from heart disease than those who had the most.1
This confirms other studies, such as by the prestigious journal Nature, that showed that people with heart disease have significantly lower testosterone than healthy people.2 Low testosterone does not cause heart disease, but letting your testosterone levels drop as you get older appears to be a disastrous for your heart.
The take home message from these studies is that testosterone can improve your health. Heart disease is the number one killer of men and women, and if we can reduce the risk of developing this debilitating problem, we can potentially help you live longer and better.
If you have low testosterone levels, does raising testosterone make the risk of having a heart attack go away? Researchers in another study sought answers to this question. They studied testosterone’s effects on animals. They evaluated five groups of animals. In four of the groups, they stopped the animals’ ability to make testosterone, leaving one group with normal testosterone. They then induced heart disease in all the animals by feeding them a diet that gives humans heart disease.
In the four groups who could not produce testosterone, two got testosterone, one got a nutrient that raises testosterone naturally, and the other got a placebo. The results were shocking. The animals that got only a placebo and did not receive testosterone developed heart disease. In the other groups who had testosterone, heart disease protection was noted.3
Other studies that had evaluated raising testosterone levels also revealed evidence that raising low testosterone levels improved heart health.4
Testosterone works its magic on your heart in several different ways. It helps prevent internal blood clotting,5 increases blood flow to the heart6 and gives you better endothelial function,7 which can help improve your blood pressure. In addition it can increase HDL cholesterol levels8 , which has always been a proven benefit to decrease heart disease.
In addition to the heart benefits of higher testosterone levels, it can also help improve your quality of life. It does multiple actions to accomplish this. With more normal levels, you’ll enjoy:
- an increase of muscle strength, power and tone
- a decrease in body fat, which can help you lose weight
- an increase in insulin sensitivity , which can lower your blood sugar and potentially decrease your risk of developing diabetes
- an increase in endurance, energy and mobility
- a greater sense of well-being (you “feel” better)
- an improved mood and emotions
- denser bones and less chance of osteoporosis
- an increase is sexual potency
- an improved mental function and focu
There are several methods available to raise your testosterone. Testosterone pellets, creams, gels, and injections can all do this. The best method for you depends on a variety of factors that should be discussed with your physician. In addition, a knowledgeable physician who prescribes this hormone should also discuss with you the potential risks associated with its use.
If you want to potentially live longer with better quality of life, look in to making sure your testosterone levels are pushed to normal ranges as you grow older. If you’re found to have “Low T”, consider getting your testosterone levels boosted through a physician specializing in anti-aging medicine and begin testosterone supplementation before you develop heart disease naturally.
1 Hyde, Z. et. al. “Low Free Testosterone Predicts Mortality…” The Journal of Clinical Endocrinology & Metabolism. October 19, 2011 jc.2011-1617.
2 “Low testosterone levels are associated with CVD risk.” Nat Rev Endocrinol. 2011 Oct 21;7(11):632.
3 Alexandersen, P. , Haarbo, J., Byrjalsen, I., Lawaetz, H., Christiansen, C. “Natural Androgens Inhibit Male Atherosclerosis.” Circulation Research. 1999; 84: 813-819.
4 Cunningham, G., Toma, S. “Why Is Androgen Replacement in Males Controversial?.” The Journal of Clinical Endocrinology & Metabolism January 1, 2011 vol. 96 no. 1, 38-52.
5 Ajayi AA. “Testosterone increases platelet thromboxane A2 receptor density.” Circulation. 1995. 91:2740-2747.
6 Webb CM, McNeill JG, Hayward CS, Zeegler D, Collins P. “Effect of testosterone on coronary vasomotor regulation in men with coronary heart disease.” Circulation. 1999. 100:1690-1693.
7 Ong PSL, Patrizi G, Chong WCF, Webb CM, Haywar’d CS, Collins P. “Testosterone enhances flow mediated brachial artery reactivity in men with coronary artery disease.” Am J Cardiol. 2000. 85:14-17.
8 Vermeulen, A. “Androgen Replacement Therapy in the Aging Male “” A Critical Evaluation.” The Journal of Clinical Endocrinology & Metabolism June 1, 2001 vol. 86 no. 6 2380-2390